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Chromatin modifications sequentially enhance ErbB2 expression in ErbB2 positive breast cancers

ErbB2 gene amplification occurs in 20–25% of breast cancers, and its therapeutic targeting has markedly improved survival of such patients in the adjuvant setting. However resistance to these therapies can develop. Because epigenetic mechanisms can importantly influence oncogene expression and be dr...

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Autori principali: Mungamuri, Sathish Kumar, Murk, William, Grumolato, Luca, Bernstein, Emily, Aaronson, Stuart A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905738/
https://ncbi.nlm.nih.gov/pubmed/24120871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.09.009
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