Psoriasiform skin disease in transgenic pigs with high-copy ectopic expression of human integrins α2 and β1

Psoriasis is a complex human-specific disease characterized by perturbed keratinocyte proliferation and a pro-inflammatory environment in the skin. Porcine skin architecture and immunity are very similar to that in humans, rendering the pig a suitable animal model for studying the biology and treatm...

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Detalhes bibliográficos
Publicado no:Dis Model Mech
Main Authors: Staunstrup, Nicklas Heine, Stenderup, Karin, Mortensen, Sidsel, Primo, Maria Nascimento, Rosada, Cecilia, Steiniche, Torben, Liu, Ying, Li, Rong, Schmidt, Mette, Purup, Stig, Dagnæs-Hansen, Frederik, Schrøder, Lisbeth Dahl, Svensson, Lars, Petersen, Thomas Kongstad, Callesen, Henrik, Bolund, Lars, Mikkelsen, Jacob Giehm
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5536904/
https://ncbi.nlm.nih.gov/pubmed/28679670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.028662
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