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Chromosome mis-segregation generates cell cycle-arrested cells with complex karyotypes that are eliminated by the immune system
Aneuploidy, a state of karyotype imbalance, is a hallmark of cancer. Changes in chromosome copy number have been proposed to drive disease by modulating the dosage of cancer driver genes and by promoting cancer genome evolution. Given the potential of cells with abnormal karyotypes to become cancero...
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| izdano v: | Dev Cell |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5536848/ https://ncbi.nlm.nih.gov/pubmed/28633018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.05.022 |
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