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Substrate conformational transitions in the active site of chorismate mutase: Their role in the catalytic mechanism
Chorismate mutase acts at the first branch-point of aromatic amino acid biosynthesis and catalyzes the conversion of chorismate to prephenate. The results of molecular dynamics simulations of the substrate in solution and in the active site of chorismate mutase are reported. Two nonreactive conforme...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The National Academy of Sciences
2001
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC55368/ https://ncbi.nlm.nih.gov/pubmed/11481470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.141230998 |
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