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Substrate conformational transitions in the active site of chorismate mutase: Their role in the catalytic mechanism
Chorismate mutase acts at the first branch-point of aromatic amino acid biosynthesis and catalyzes the conversion of chorismate to prephenate. The results of molecular dynamics simulations of the substrate in solution and in the active site of chorismate mutase are reported. Two nonreactive conforme...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC55368/ https://ncbi.nlm.nih.gov/pubmed/11481470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.141230998 |
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