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Refined molecular hinge between allosteric and catalytic domain determines allosteric regulation and stability of fungal chorismate mutase

The yeast chorismate mutase is regulated by tyrosine as feedback inhibitor and tryptophan as crosspathway activator. The monomer consists of a catalytic and a regulatory domain covalently linked by the loop L220s (212–226), which functions as a molecular hinge. Two monomers form the active dimeric e...

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Hlavní autoři: Helmstaedt, Kerstin, Heinrich, Gabriele, Lipscomb, William N., Braus, Gerhard H.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2002
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC124454/
https://ncbi.nlm.nih.gov/pubmed/11997452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.092130899
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