Regional Glutamine Deficiency in Tumours Promotes De-differentiation through Inhibition of Histone Demethylation

Poorly organized tumour vasculature often results in areas of limited nutrient supply and hypoxia. Despite our understanding of solid tumour responses to hypoxia, how nutrient deprivation regionally affects tumour growth and therapeutic response is poorly understood. Here, we show the core region of...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Nat Cell Biol
Päätekijät: Pan, Min, Reid, Michael A., Lowman, Xazmin H., Kulkarni, Rajan P., Tran, Thai Q., Liu, Xiaojing, Yang, Ying, Hernandez-Davies, Jenny E., Rosales, Kimberly K., Li, Haiqing, Hugo, Willy, Song, Chunying, Xu, Xiangdong, Schones, Dustin E., Ann, David K., Gradinaru, Viviana, Lo, Roger S., Locasale, Jason W., Kong, Mei
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5536113/
https://ncbi.nlm.nih.gov/pubmed/27617932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3410
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