Regional Glutamine Deficiency in Tumours Promotes De-differentiation through Inhibition of Histone Demethylation

Poorly organized tumour vasculature often results in areas of limited nutrient supply and hypoxia. Despite our understanding of solid tumour responses to hypoxia, how nutrient deprivation regionally affects tumour growth and therapeutic response is poorly understood. Here, we show the core region of...

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Publicado en:Nat Cell Biol
Main Authors: Pan, Min, Reid, Michael A., Lowman, Xazmin H., Kulkarni, Rajan P., Tran, Thai Q., Liu, Xiaojing, Yang, Ying, Hernandez-Davies, Jenny E., Rosales, Kimberly K., Li, Haiqing, Hugo, Willy, Song, Chunying, Xu, Xiangdong, Schones, Dustin E., Ann, David K., Gradinaru, Viviana, Lo, Roger S., Locasale, Jason W., Kong, Mei
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5536113/
https://ncbi.nlm.nih.gov/pubmed/27617932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3410
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