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Mechanistic Basis for the Binding of RGD- and AGDV-Peptides to the Platelet Integrin αIIbβ3

Binding of soluble fibrinogen to the activated conformation of the integrin αIIbβ3 is required for platelet aggregation and is mediated exclusively by the C-terminal AGDV-containing dodecapeptide (γC-12) sequence of the fibrinogen γ chain. However, peptides containing the Arg-Gly-Asp (RGD) sequences...

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Detaylı Bibliyografya
Yayımlandı:Biochemistry
Asıl Yazarlar: Kononova, Olga, Litvinov, Rustem I., Blokhin, Dmitry S., Klochkov, Vladimir V., Weisel, John W., Bennett, Joel S., Barsegov, Valeri
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5536102/
https://ncbi.nlm.nih.gov/pubmed/28277676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01113
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