BRD9 Inhibition, Alone or in Combination with Cytostatic Compounds as a Therapeutic Approach in Rhabdoid Tumors

Rhabdoid tumors (RT) are malignant neoplasms of early childhood. Despite intensive therapy, survival is poor and new treatment approaches are required. The only recurrent mutations in these tumors affect SMARCB1 and less commonly SMARCA4, both subunits of the chromatin remodeling complex SWItch/Sucr...

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Bibliographic Details
Published in:	Int J Mol Sci
Main Authors:	Krämer, Katja F., Moreno, Natalia, Frühwald, Michael C., Kerl, Kornelius
Format:	Artigo
Language:	Inglês
Published:	MDPI 2017
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5536025/ https://ncbi.nlm.nih.gov/pubmed/28714904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18071537
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BRD9 Inhibition, Alone or in Combination with Cytostatic Compounds as a Therapeutic Approach in Rhabdoid Tumors

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