NAD(+) repletion improves muscle function in muscular dystrophy and counters global PARylation

Neuromuscular diseases are often caused by inherited mutations that lead to progressive skeletal muscle weakness and degeneration. In diverse populations of normal healthy mice, we observed correlations between the abundance of mRNA transcripts related to mitochondrial biogenesis, the dystrophin-sar...

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Библиографические подробности
Опубликовано в: :Sci Transl Med
Главные авторы: Ryu, Dongryeol, Zhang, Hongbo, Ropelle, Eduardo R., Sorrentino, Vincenzo, Mázala, Davi A. G., Mouchiroud, Laurent, Marshall, Philip L., Campbell, Matthew D., Ali, Amir Safi, Knowels, Gary M., Bellemin, Stéphanie, Iyer, Shama R., Wang, Xu, Gariani, Karim, Sauve, Anthony A., Cantó, Carles, Conley, Kevin E., Walter, Ludivine, Lovering, Richard M., Chin, Eva R., Jasmin, Bernard J., Marcinek, David J., Menzies, Keir J., Auwerx, Johan
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5535761/
https://ncbi.nlm.nih.gov/pubmed/27798264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf5504
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