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NAD(+) repletion improves muscle function in muscular dystrophy and counters global PARylation

Neuromuscular diseases are often caused by inherited mutations that lead to progressive skeletal muscle weakness and degeneration. In diverse populations of normal healthy mice, we observed correlations between the abundance of mRNA transcripts related to mitochondrial biogenesis, the dystrophin-sar...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Ryu, Dongryeol, Zhang, Hongbo, Ropelle, Eduardo R., Sorrentino, Vincenzo, Mázala, Davi A. G., Mouchiroud, Laurent, Marshall, Philip L., Campbell, Matthew D., Ali, Amir Safi, Knowels, Gary M., Bellemin, Stéphanie, Iyer, Shama R., Wang, Xu, Gariani, Karim, Sauve, Anthony A., Cantó, Carles, Conley, Kevin E., Walter, Ludivine, Lovering, Richard M., Chin, Eva R., Jasmin, Bernard J., Marcinek, David J., Menzies, Keir J., Auwerx, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5535761/
https://ncbi.nlm.nih.gov/pubmed/27798264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf5504
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