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Mechanistic Model for Enantioselective Intramolecular Alkene Cyanoamidation via Palladium-Catalyzed C–CN Bond Activation

We studied key aspects of the mechanism of Pd-catalyzed C–CN bond activation and intramolecular enantioselective alkene cyanoamidation. An Abboud–Abraham–Kamlet–Taft (AAKT) linear solvation energy relationship (LSER) model for enantioselectivity was established. We investigated the impact of Lewis a...

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Pubblicato in:J Org Chem
Autori principali: Frost, Grant B., Serratore, Nicholas A., Ogilvie, Jodi M., Douglas, Christopher J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5535300/
https://ncbi.nlm.nih.gov/pubmed/28294618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.7b00196
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