Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing

AMP-activated protein kinase (AMPK) is a central cellular energy sensor that adapts metabolism and growth to the energy state of the cell. AMPK senses the ratio of adenine nucleotides (adenylate energy charge) by competitive binding of AMP, ADP, and ATP to three sites (CBS1, CBS3, and CBS4) in its γ...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Gu, Xin, Yan, Yan, Novick, Scott J., Kovach, Amanda, Goswami, Devrishi, Ke, Jiyuan, Tan, M. H. Eileen, Wang, Lili, Li, Xiaodan, de Waal, Parker W., Webb, Martin R., Griffin, Patrick R., Xu, H. Eric, Melcher, Karsten
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5535039/
https://ncbi.nlm.nih.gov/pubmed/28615457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.793018
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