Structural basis of AMPK regulation by adenine nucleotides and glycogen

AMP-activated protein kinase (AMPK) is a central cellular energy sensor and regulator of energy homeostasis, and a promising drug target for the treatment of diabetes, obesity, and cancer. Here we present low-resolution crystal structures of the human α1β2γ1 holo-AMPK complex bound to its allosteric...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Li, Xiaodan, Wang, Lili, Zhou, X Edward, Ke, Jiyuan, de Waal, Parker W, Gu, Xin, Tan, M H Eileen, Wang, Dongye, Wu, Donghai, Xu, H Eric, Melcher, Karsten
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4650587/
https://ncbi.nlm.nih.gov/pubmed/25412657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2014.150
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