Structural basis of AMPK regulation by adenine nucleotides and glycogen

AMP-activated protein kinase (AMPK) is a central cellular energy sensor and regulator of energy homeostasis, and a promising drug target for the treatment of diabetes, obesity, and cancer. Here we present low-resolution crystal structures of the human α1β2γ1 holo-AMPK complex bound to its allosteric...

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Bibliographic Details
Published in:	Cell Res
Main Authors:	Li, Xiaodan, Wang, Lili, Zhou, X Edward, Ke, Jiyuan, de Waal, Parker W, Gu, Xin, Tan, M H Eileen, Wang, Dongye, Wu, Donghai, Xu, H Eric, Melcher, Karsten
Format:	Artigo
Language:	Inglês
Published:	Nature Publishing Group 2015
Subjects:	Original Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4650587/ https://ncbi.nlm.nih.gov/pubmed/25412657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2014.150
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Structural basis of AMPK regulation by adenine nucleotides and glycogen

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