The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome

UBE3A is a HECT domain E3 ubiquitin ligase whose dysfunction is linked to autism, Angelman syndrome, and cancer. Recently, we characterized a de novo autism-linked UBE3A mutant (UBE3A(T485A)) that disrupts phosphorylation control of UBE3A activity. Through quantitative proteomics and reporter assays...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Yi, Jason J., Paranjape, Smita R., Walker, Matthew P., Choudhury, Rajarshi, Wolter, Justin M., Fragola, Giulia, Emanuele, Michael J., Major, Michael B., Zylka, Mark J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5535025/
https://ncbi.nlm.nih.gov/pubmed/28559284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.788448
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