Dysfunction of the Ubiquitin Ligase Ube3a May Be Associated with Synaptic Pathophysiology in a Mouse Model of Huntington Disease

Huntington disease (HD) is a hereditary neurodegenerative disorder characterized by progressive cognitive, psychiatric, and motor symptoms. The disease is caused by abnormal expansion of CAG repeats in the gene encoding huntingtin, but how mutant huntingtin leads to early cognitive deficits in HD is...

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Main Authors: Maheshwari, Megha, Samanta, Ananya, Godavarthi, Swetha K., Mukherjee, Rajarshi, Jana, Nihar Ranjan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Neurobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436189/
https://ncbi.nlm.nih.gov/pubmed/22787151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.371724
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