Co-chaperone CHIP Stabilizes Aggregate-prone Malin, a Ubiquitin Ligase Mutated in Lafora Disease

Lafora disease (LD) is an autosomal recessive neurodegenerative disorder caused by mutation in either the dual specificity phosphatase laforin or ubiquitin ligase malin. A pathological hallmark of LD is the accumulation of cytoplasmic polyglucosan inclusions commonly known as Lafora bodies in both n...

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Detalles Bibliográficos
Main Authors: Rao, Sudheendra N. R., Sharma, Jaiprakash, Maity, Ranjan, Jana, Nihar Ranjan
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801266/
https://ncbi.nlm.nih.gov/pubmed/19892702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.006312
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