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HIV-1 Epitope Variability Is Associated with T Cell Receptor Repertoire Instability and Breadth

Mutational escape of HIV-1 from HIV-1-specific CD8(+) T lymphocytes (CTLs) is a major barrier for effective immune control. Each epitope typically is targeted by multiple clones with distinct T cell receptors (TCRs). While the clonal repertoire may be important for containing epitope variation, dete...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Balamurugan, Arumugam, Claiborne, Deon, Ng, Hwee L., Yang, Otto O.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533926/
https://ncbi.nlm.nih.gov/pubmed/28592539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00771-17
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