Epigenetic changes in myelofibrosis: Distinct methylation changes in the myeloid compartments and in cases with ASXL1 mutations

This is the first study to compare genome-wide DNA methylation profiles of sorted blood cells from myelofibrosis (MF) patients and healthy controls. We found that differentially methylated CpG sites located to genes involved in ‘cancer’ and ‘embryonic development’ in MF CD34+ cells, in ‘inflammatory...

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Vydáno v:Sci Rep
Hlavní autoři: Nielsen, Helene Myrtue, Andersen, Christen Lykkegaard, Westman, Maj, Kristensen, Lasse Sommer, Asmar, Fazila, Kruse, Torben Arvid, Thomassen, Mads, Larsen, Thomas Stauffer, Skov, Vibe, Hansen, Lise Lotte, Bjerrum, Ole Weis, Hasselbalch, Hans Carl, Punj, Vasu, Grønbæk, Kirsten
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533802/
https://ncbi.nlm.nih.gov/pubmed/28754985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07057-3
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