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A novel proton transfer mechanism in the SLC11 family of divalent metal ion transporters
In humans, the H(+)-coupled Fe(2+) transporter DMT1 (SLC11A2) is essential for proper maintenance of iron homeostasis. While X-ray diffraction has recently unveiled the structure of the bacterial homologue ScaDMT as a LeuT-fold transporter, the exact mechanism of H(+)-cotransport has remained elusiv...
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| Udgivet i: | Sci Rep |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5533754/ https://ncbi.nlm.nih.gov/pubmed/28754960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06446-y |
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