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Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds

In humans, the divalent metal ion transporter-1 (DMT1) mediates the transport of ferrous iron across the apical membrane of enterocytes. Hence, its inhibition could be beneficial for the treatment of iron overload disorders. Here we characterize the interaction of aromatic bis-isothiourea-substitute...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Manatschal, Cristina, Pujol-Giménez, Jonai, Poirier, Marion, Reymond, Jean-Louis, Hediger, Matthias A, Dutzler, Raimund
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6917499/
https://ncbi.nlm.nih.gov/pubmed/31804182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51913
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