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A novel proton transfer mechanism in the SLC11 family of divalent metal ion transporters

In humans, the H(+)-coupled Fe(2+) transporter DMT1 (SLC11A2) is essential for proper maintenance of iron homeostasis. While X-ray diffraction has recently unveiled the structure of the bacterial homologue ScaDMT as a LeuT-fold transporter, the exact mechanism of H(+)-cotransport has remained elusiv...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Pujol-Giménez, Jonai, Hediger, Matthias A., Gyimesi, Gergely
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533754/
https://ncbi.nlm.nih.gov/pubmed/28754960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06446-y
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