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The Hydroxyl Side Chain of a Highly Conserved Serine Residue Is Required for Cation Selectivity and Substrate Transport in the Glial Glutamate Transporter GLT-1/SLC1A2

Glutamate transporters maintain synaptic concentration of the excitatory neurotransmitter below neurotoxic levels. Their transport cycle consists of cotransport of glutamate with three sodium ions and one proton, followed by countertransport of potassium. Structural studies proposed that a highly co...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Simonin, Alexandre, Montalbetti, Nicolas, Gyimesi, Gergely, Pujol-Giménez, Jonai, Hediger, Matthias A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683268/
https://ncbi.nlm.nih.gov/pubmed/26483543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.689836
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