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Sizing clinical trials when comparing bivariate time-to-event outcomes

Clinical trials with multiple primary time-to-event outcomes are common. Use of multiple endpoints creates challenges in the evaluation of power and the calculation of sample size during trial design particularly for time-to-event outcomes. We present methods for calculating the power and sample siz...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Stat Med
Main Authors: Sugimoto, Tomoyuki, Hamasaki, Toshimitsu, Evans, Scott, Sozu, Takashi
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533151/
https://ncbi.nlm.nih.gov/pubmed/28120524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.7225
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