The CD4 molecule on CD8(+) T lymphocytes directly enhances the immune response to viral and cellular antigens

CD8(+) T lymphocytes play a major role in cellular-mediated immune responses to foreign antigen. We have previously demonstrated that costimulation of purified human CD8(+) T cells induces de novo expression of the CD4 molecule and that ligation of CD4 on this cell type modulates CD8(+) T cell activ...

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Bibliographic Details
Main Authors: Kitchen, Scott G., Whitmire, Jason K., Jones, Nicole R., Galic, Zoran, Kitchen, Christina M. R., Ahmed, Rafi, Zack, Jerome A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC553300/
https://ncbi.nlm.nih.gov/pubmed/15731353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406603102
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