Upregulation of CD4 on CD8(+) T cells: CD4(dim)CD8(bright) T cells constitute an activated phenotype of CD8(+) T cells

Aside from an intermediate stage in thymic T-cell development, the expression of CD4 and CD8 is generally thought to be mutually exclusive, associated with helper or cytotoxic T-cell functions, respectively. Stimulation of CD8(+) T cells, however, induces the de novo expression of CD4. We demonstrat...

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Bibliographic Details
Main Authors: Sullivan, Yvonne B, Landay, Alan L, Zack, Jerome A, Kitchen, Scott G, Al-Harthi, Lena
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2001
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1783254/
https://ncbi.nlm.nih.gov/pubmed/11454056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2567.2001.01243.x
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