Chemoenzymatic total synthesis and structural diversification of tylactone-based macrolide antibiotics through late-stage polyketide assembly, tailoring, and C-H functionalization

Polyketide synthases (PKSs) represent a powerful catalytic platform capable of effecting multiple carbon-carbon bond forming reactions and oxidation state adjustments. We explored the functionality of two terminal PKS modules that produce the 16-membered tylosin macrocycle, using them as biocatalyst...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Lowell, Andrew N., DeMars, Matthew D., Slocum, Samuel T., Yu, Fengan, Anand, Krithika, Chemler, Joseph A., Korakavi, Nisha, Priessnitz, Jennifer K., Park, Sung Ryeol, Koch, Aaron A., Schultz, Pamela J., Sherman, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5532807/
https://ncbi.nlm.nih.gov/pubmed/28525276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b02875
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