Novel C-Ring-Hydroxy-Substituted Controlled Deactivation Cannabinergic Analogues

In pursuit of safer controlled-deactivation cannabinoids with high potency and short duration of action, we report the design, synthesis, and pharmacological evaluation of novel C9- and C11-hydroxy-substituted hexahydrocannabinol (HHC) and tetrahydrocannabinol (THC) analogues in which a seven atom l...

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Vydáno v:J Med Chem
Hlavní autoři: Kulkarni, Shashank, Nikas, Spyros P., Sharma, Rishi, Jiang, Shan, Paronis, Carol A., Leonard, Michael Z., Zhang, Bin, Honrao, Chandrashekhar, Mallipeddi, Srikrishnan, Raghav, Jimit Girish, Benchama, Othman, Jarbe, Torbjorn U. C., Bergman, Jack, Makriyannis, Alexandros
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5532543/
https://ncbi.nlm.nih.gov/pubmed/27367336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00717
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