Probing the Carboxyester Side Chain in Controlled Deactivation (−)-Δ(8)-Tetrahydrocannabinols

[Image: see text] We recently reported on a controlled deactivation/detoxification approach for obtaining cannabinoids with improved druggability. Our design incorporates a metabolically labile ester group at strategic positions within the THC structure. We have now synthesized a series of (−)-Δ(8)-...

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Pubblicato in:J Med Chem
Autori principali: Nikas, Spyros P., Sharma, Rishi, Paronis, Carol A., Kulkarni, Shashank, Thakur, Ganesh A., Hurst, Dow, Wood, JodiAnne T., Gifford, Roger S., Rajarshi, Girija, Liu, Yingpeng, Raghav, Jimit Girish, Guo, Jason Jianxin, Järbe, Torbjörn U.C., Reggio, Patricia H., Bergman, Jack, Makriyannis, Alexandros
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2014
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4306527/
https://ncbi.nlm.nih.gov/pubmed/25470070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501165d
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