AM2389, a high-affinity, in vivo potent CB(1)-receptor-selective cannabinergic ligand as evidenced by drug discrimination in rats and hypothermia testing in mice

RATIONALE: The endocannabinoid signaling system (ECS) has been targeted for developing novel therapeutics since ECS dysfunction has been implicated in various pathologies. Current focus is on chemical modifications of the hexahydrocannabinol (HHC) nabilone (Cesamet(®)). OBJECTIVE: To characterize th...

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Bibliographische Detailangaben
Hauptverfasser: Järbe, Torbjörn U. C., Tai, Sherrica, LeMay, Brian J., Nikas, Spyros P., Shukla, Vidyanand G., Zvonok, Alexander, Makriyannis, Alexandros
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291515/
https://ncbi.nlm.nih.gov/pubmed/21989802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-011-2491-1
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