AM2389, a high-affinity, in vivo potent CB(1)-receptor-selective cannabinergic ligand as evidenced by drug discrimination in rats and hypothermia testing in mice

RATIONALE: The endocannabinoid signaling system (ECS) has been targeted for developing novel therapeutics since ECS dysfunction has been implicated in various pathologies. Current focus is on chemical modifications of the hexahydrocannabinol (HHC) nabilone (Cesamet(®)). OBJECTIVE: To characterize th...

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Detalhes bibliográficos
Main Authors: Järbe, Torbjörn U. C., Tai, Sherrica, LeMay, Brian J., Nikas, Spyros P., Shukla, Vidyanand G., Zvonok, Alexander, Makriyannis, Alexandros
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291515/
https://ncbi.nlm.nih.gov/pubmed/21989802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-011-2491-1
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