Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor

Infants with defects in the interleukin 10 receptor (IL10R) develop very early onset inflammatory bowel disease. Whether IL10R regulates lamina propria macrophage function during infant development in mice and whether macrophage-intrinsic IL10R signaling is required to prevent colitis in infancy is...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Redhu, Naresh S, Bakthavatchalu, Vasudevan, Conaway, Evan A, Shouval, Dror S, Tsou, Amy, Goettel, Jeremy A, Biswas, Amlan, Wang, Chuanwu, Field, Michael, Muller, Werner, Bleich, Andre, Li, Ning, Gerber, Georg K, Bry, Lynn, Fox, James G, Snapper, Scott B, Horwitz, Bruce H
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531923/
https://ncbi.nlm.nih.gov/pubmed/28678006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27652
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