WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis

Mutations in Wiskott–Aldrich syndrome protein (WASP) cause autoimmune sequelae including colitis. Yet, how WASP mediates mucosal homeostasis is not fully understood. Here we show that WASP-mediated regulation of anti-inflammatory macrophages is critical for mucosal homeostasis and immune tolerance....

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Biswas, Amlan, Shouval, Dror S., Griffith, Alexandra, Goettel, Jeremy A., Field, Michael, Kang, Yu Hui, Konnikova, Liza, Janssen, Erin, Redhu, Naresh Singh, Thrasher, Adrian J., Chatila, Talal, Kuchroo, Vijay K., Geha, Raif S, Notarangelo, Luigi D., Pai, Sung-Yun, Horwitz, Bruce H., Snapper, Scott B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934380/
https://ncbi.nlm.nih.gov/pubmed/29725003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03670-6
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