WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis

Mutations in Wiskott–Aldrich syndrome protein (WASP) cause autoimmune sequelae including colitis. Yet, how WASP mediates mucosal homeostasis is not fully understood. Here we show that WASP-mediated regulation of anti-inflammatory macrophages is critical for mucosal homeostasis and immune tolerance....

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Publicado en:Nat Commun
Autores principales: Biswas, Amlan, Shouval, Dror S., Griffith, Alexandra, Goettel, Jeremy A., Field, Michael, Kang, Yu Hui, Konnikova, Liza, Janssen, Erin, Redhu, Naresh Singh, Thrasher, Adrian J., Chatila, Talal, Kuchroo, Vijay K., Geha, Raif S, Notarangelo, Luigi D., Pai, Sung-Yun, Horwitz, Bruce H., Snapper, Scott B.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934380/
https://ncbi.nlm.nih.gov/pubmed/29725003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03670-6
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