Interval dosing with the HDAC inhibitor vorinostat effectively reverses HIV latency

BACKGROUND. The histone deacetylase (HDAC) inhibitor vorinostat (VOR) can increase HIV RNA expression in vivo within resting CD4(+) T cells of aviremic HIV(+) individuals. However, while studies of VOR or other HDAC inhibitors have reported reversal of latency, none has demonstrated clearance of lat...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:J Clin Invest
Main Authors: Archin, Nancie M., Kirchherr, Jennifer L., Sung, Julia A.M., Clutton, Genevieve, Sholtis, Katherine, Xu, Yinyan, Allard, Brigitte, Stuelke, Erin, Kashuba, Angela D., Kuruc, Joann D., Eron, Joseph, Gay, Cynthia L., Goonetilleke, Nilu, Margolis, David M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2017
Assuntos:
Clinical Medicine
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531421/
https://ncbi.nlm.nih.gov/pubmed/28714868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92684
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares