Interval dosing with the HDAC inhibitor vorinostat effectively reverses HIV latency

BACKGROUND. The histone deacetylase (HDAC) inhibitor vorinostat (VOR) can increase HIV RNA expression in vivo within resting CD4(+) T cells of aviremic HIV(+) individuals. However, while studies of VOR or other HDAC inhibitors have reported reversal of latency, none has demonstrated clearance of lat...

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Foilsithe in:J Clin Invest
Main Authors: Archin, Nancie M., Kirchherr, Jennifer L., Sung, Julia A.M., Clutton, Genevieve, Sholtis, Katherine, Xu, Yinyan, Allard, Brigitte, Stuelke, Erin, Kashuba, Angela D., Kuruc, Joann D., Eron, Joseph, Gay, Cynthia L., Goonetilleke, Nilu, Margolis, David M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2017
Ábhair:
Clinical Medicine
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531421/
https://ncbi.nlm.nih.gov/pubmed/28714868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92684
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