Mutations in 5-methylcytosine oxidase TET2 and RhoA cooperatively disrupt T cell homeostasis

Angioimmunoblastic T cell lymphoma (AITL) represents a distinct, aggressive form of peripheral T cell lymphoma with a dismal prognosis. Recent exome sequencing in patients with AITL has revealed the frequent coexistence of somatic mutations in the Rho GTPase RhoA (RhoA(G17V)) and loss-of-function mu...

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Bibliographische Detailangaben
Veröffentlicht in:J Clin Invest
Hauptverfasser: Zang, Shengbing, Li, Jia, Yang, Haiyan, Zeng, Hongxiang, Han, Wei, Zhang, Jixiang, Lee, Minjung, Moczygemba, Margie, Isgandarova, Sevinj, Yang, Yaling, Zhou, Yubin, Rao, Anjana, You, M. James, Sun, Deqiang, Huang, Yun
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531410/
https://ncbi.nlm.nih.gov/pubmed/28691928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92026
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