Two rheumatoid arthritis–specific autoantigens correlate microbial immunity with autoimmune responses in joints

In rheumatoid arthritis (RA), immunological triggers at mucosal sites, such as the gut microbiota, may promote autoimmunity that affects joints. Here, we used discovery-based proteomics to detect HLA-DR–presented peptides in synovia or peripheral blood mononuclear cells and identified 2 autoantigens...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Pianta, Annalisa, Arvikar, Sheila L., Strle, Klemen, Drouin, Elise E., Wang, Qi, Costello, Catherine E., Steere, Allen C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531397/
https://ncbi.nlm.nih.gov/pubmed/28650341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI93450
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