Impact of somatic PI3K pathway and ERBB family mutations on pathological complete response (pCR) in HER2-positive breast cancer patients who received neoadjuvant HER2-targeted therapies

BACKGROUND: The Cancer Genome Atlas analysis revealed that somatic EGFR, receptor tyrosine-protein kinase erbB-2 (ERBB2), Erb-B2 receptor tyrosine kinase 3 (ERBB3) and Erb-B2 receptor tyrosine kinase 4 (ERBB4) gene mutations (ERBB family mutations) occur alone or co-occur with somatic mutations in t...

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Detalhes bibliográficos
Publicado no:Breast Cancer Res
Main Authors: Toomey, Sinead, Eustace, Alexander J., Fay, Joanna, Sheehan, Katherine M., Carr, Aoife, Milewska, Malgorzata, Madden, Stephen F., Teiserskiene, Ausra, Kay, Elaine W., O’Donovan, Norma, Gallagher, William, Grogan, Liam, Breathnach, Oscar, Walshe, Janice, Kelly, Catherine, Moulton, Brian, Kennedy, M. John, Gullo, Guiseppe, Hill, Arnold D., Power, Colm, Duke, Deirdre, Hambly, Niamh, Crown, John, Hennessy, Bryan T.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5530949/
https://ncbi.nlm.nih.gov/pubmed/28750640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-017-0883-9
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