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Characterization of Cardiac Glycoside Natural Products as Potent Inhibitors of DNA Double-Strand Break Repair by a Whole-Cell Double Immunofluorescence Assay

Small-molecule inhibitors of DNA repair pathways are being intensively investigated as primary and adjuvant chemotherapies. We report the discovery that cardiac glycosides, natural products in clinical use for the treatment of heart failure and atrial arrhythmia, are potent inhibitors of DNA double-...

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Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Surovtseva, Yulia V., Jairam, Vikram, Salem, Ahmed F., Sundaram, Ranjini K., Bindra, Ranjit S., Herzon, Seth B.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5530877/
https://ncbi.nlm.nih.gov/pubmed/26927829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b00162
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