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Trifluorothymidine exhibits potent antitumor activity via the induction of DNA double-strand breaks
TAS-102 is an oral anticancer drug composed of trifluorothymidine (TFT) and TPI (an inhibitor of thymidine phosphorylase that strongly inhibits the biodegradation of TFT). Similar to 5-fluorouracil (5FU) and 5-fluoro-2′-deoxyuridine (FdUrd), TFT also inhibits thymidylate synthase (TS), a rate-limiti...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
D.A. Spandidos
2011
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3440718/ https://ncbi.nlm.nih.gov/pubmed/22977515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2011.244 |
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