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Bivariate Genomic Footprinting Detects Changes in Transcription Factor Activity

In response to activating signals, transcription factors (TFs) bind DNA and regulate gene expression. TF binding can be measured by protection of the bound sequence from DNase digestion (i.e. footprint). Here, we report that 80% of TF binding motifs do not show a measurable footprint, partly due to...

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Detalles Bibliográficos
Publicado en:Cell Rep
Main Authors: Baek, Songjoon, Goldstein, Ido, Hager, Gordon L.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5530758/
https://ncbi.nlm.nih.gov/pubmed/28538187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.05.003
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