Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis

Isocitrate lyase (ICL, types 1 and 2) is the first enzyme of the glyoxylate shunt, an essential pathway for Mycobacterium tuberculosis (Mtb) during the persistent phase of human TB infection. Here, we report 2-vinyl-d-isocitrate (2-VIC) as a mechanism-based inactivator of Mtb ICL1 and ICL2. The enzy...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Pham, Truc V., Murkin, Andrew S., Moynihan, Margaret M., Harris, Lawrence, Tyler, Peter C., Shetty, Nishant, Sacchettini, James C., Huang, Hsiao-ling, Meek, Thomas D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5530696/
https://ncbi.nlm.nih.gov/pubmed/28679637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706134114
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