Itaconate is a covalent inhibitor of the Mycobacterium tuberculosis isocitrate lyase

Itaconate is a mammalian antimicrobial metabolite that inhibits the isocitrate lyases (ICLs) of Mycobacterium tuberculosis. Herein, we report that ICLs form a covalent adduct with itaconate through their catalytic cysteine residue. These results reveal atomic details of itaconate inhibition and prov...

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Udgivet i:RSC Med Chem
Main Authors: Kwai, Brooke X. C., Collins, Annabelle J., Middleditch, Martin J., Sperry, Jonathan, Bashiri, Ghader, Leung, Ivanhoe K. H.
Format: Artigo
Sprog:Inglês
Udgivet: RSC 2020
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8130629/
https://ncbi.nlm.nih.gov/pubmed/34046597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00301h
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