Development of NMR and thermal shift assays for the evaluation of Mycobacterium tuberculosis isocitrate lyase inhibitors

The enzymes isocitrate lyase (ICL) isoforms 1 and 2 are essential for Mycobacterium tuberculosis survival within macrophages during latent tuberculosis (TB). As such, ICLs are attractive therapeutic targets for the treatment of tuberculosis. However, there are few biophysical assays that are availab...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Bhusal, Ram Prasad, Patel, Krunal, Kwai, Brooke X. C., Swartjes, Anne, Bashiri, Ghader, Reynisson, Jóhannes, Sperry, Jonathan, Leung, Ivanhoe K. H.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2017
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072051/
https://ncbi.nlm.nih.gov/pubmed/30108733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00456g
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados