Mutant p53 potentiates the oncogenic effects of insulin by inhibiting the tumor suppressor DAB2IP

Obesity and type 2 diabetes are significant risk factors for malignancies, being associated with chronic inflammation and hyperinsulinemia. In this context, insulin can synergize with inflammation to promote proliferation, survival, and dissemination of cancer cells. Point mutation of p53 is a frequ...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Valentino, Elena, Bellazzo, Arianna, Di Minin, Giulio, Sicari, Daria, Apollonio, Mattia, Scognamiglio, Giosuè, Di Bonito, Maurizio, Botti, Gerardo, Del Sal, Giannino, Collavin, Licio
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2017
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5530663/
https://ncbi.nlm.nih.gov/pubmed/28667123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700996114
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