Mutant p53 potentiates the oncogenic effects of insulin by inhibiting the tumor suppressor DAB2IP

Obesity and type 2 diabetes are significant risk factors for malignancies, being associated with chronic inflammation and hyperinsulinemia. In this context, insulin can synergize with inflammation to promote proliferation, survival, and dissemination of cancer cells. Point mutation of p53 is a frequ...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Valentino, Elena, Bellazzo, Arianna, Di Minin, Giulio, Sicari, Daria, Apollonio, Mattia, Scognamiglio, Giosuè, Di Bonito, Maurizio, Botti, Gerardo, Del Sal, Giannino, Collavin, Licio
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5530663/
https://ncbi.nlm.nih.gov/pubmed/28667123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700996114
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