Mutant p53 potentiates the oncogenic effects of insulin by inhibiting the tumor suppressor DAB2IP

Obesity and type 2 diabetes are significant risk factors for malignancies, being associated with chronic inflammation and hyperinsulinemia. In this context, insulin can synergize with inflammation to promote proliferation, survival, and dissemination of cancer cells. Point mutation of p53 is a frequ...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Valentino, Elena, Bellazzo, Arianna, Di Minin, Giulio, Sicari, Daria, Apollonio, Mattia, Scognamiglio, Giosuè, Di Bonito, Maurizio, Botti, Gerardo, Del Sal, Giannino, Collavin, Licio
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5530663/
https://ncbi.nlm.nih.gov/pubmed/28667123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700996114
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