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Mutant p53 potentiates the oncogenic effects of insulin by inhibiting the tumor suppressor DAB2IP
Obesity and type 2 diabetes are significant risk factors for malignancies, being associated with chronic inflammation and hyperinsulinemia. In this context, insulin can synergize with inflammation to promote proliferation, survival, and dissemination of cancer cells. Point mutation of p53 is a frequ...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5530663/ https://ncbi.nlm.nih.gov/pubmed/28667123 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700996114 |
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