Mutant p53 potentiates the oncogenic effects of insulin by inhibiting the tumor suppressor DAB2IP

Obesity and type 2 diabetes are significant risk factors for malignancies, being associated with chronic inflammation and hyperinsulinemia. In this context, insulin can synergize with inflammation to promote proliferation, survival, and dissemination of cancer cells. Point mutation of p53 is a frequ...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Valentino, Elena, Bellazzo, Arianna, Di Minin, Giulio, Sicari, Daria, Apollonio, Mattia, Scognamiglio, Giosuè, Di Bonito, Maurizio, Botti, Gerardo, Del Sal, Giannino, Collavin, Licio
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2017
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5530663/
https://ncbi.nlm.nih.gov/pubmed/28667123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700996114
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