Burn-induced muscle metabolic derangements and mitochondrial dysfunction are associated with activation of HIF-1α and mTORC1: Role of protein farnesylation

Metabolic derangements are a clinically significant complication of major trauma (e.g., burn injury) and include various aspects of metabolism, such as insulin resistance, muscle wasting, mitochondrial dysfunction and hyperlactatemia. Nonetheless, the molecular pathogenesis and the relation between...

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Published in:Sci Rep
Main Authors: Nakazawa, Harumasa, Ikeda, Kazuhiro, Shinozaki, Shohei, Kobayashi, Masayuki, Ikegami, Yuichi, Fu, Ming, Nakamura, Tomoyuki, Yasuhara, Shingo, Yu, Yong-Ming, Martyn, J. A. Jeevendra, Tompkins, Ronald G., Shimokado, Kentaro, Yorozu, Tomoko, Ito, Hideki, Inoue, Satoshi, Kaneki, Masao
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5529411/
https://ncbi.nlm.nih.gov/pubmed/28747716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07011-3
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