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The Democratization of Gene Editing: Insights from site-specific cleavage and double-strand break repair

DNA double-strand breaks (DSBs) are dangerous lesions that if not properly repaired can lead to genomic change or cell death. Organisms have developed several pathways and have many factors devoted to repairing DSBs, which broadly occur by homologous recombination that relies on an identical or homo...

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Bibliografiske detaljer
Udgivet i:DNA Repair (Amst)
Main Authors: Jasin, Maria, Haber, James E.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5529214/
https://ncbi.nlm.nih.gov/pubmed/27261202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2016.05.001
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